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. 2018 Aug 10;8:11987. doi: 10.1038/s41598-018-30486-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation of KCC2 and pKCC2 expression vs. Seizure suppression. (A) KCC2 and seizure suppression showed a significant positive correlation at P7, when seizures are PB-resistant. (B) pKCC2 and seizure suppression were positively correlated, but not significant at P7. (C,D) KCC2 and pKCC2 show no correlation at P10, when seizures are PB-responsive.