Table 2.

EEG Seizure Statistics (*P < 0.05, **P < 0.01, ***P < 0.001).

A) P7 seizure stats	+PB	0.5 mg/kg ANA12 + PB	2.5 mg/kg ANA12 + PB	5 mg/kg ANA12 + PB
1st hr seizure burden	1152.5 ± 71.9	1135.0 ± 83.5	1207.5 ± 71.9	1044.4 ± 90.9
2nd hr seizure burden	1109.6 ± 94.4	858.5 ± 74.3	711.7 ± 79.7	354.4 ± 61.3
2 way ANOVA F3, 174 = 6.145; P = 0.0005*** post-hoc 1st vs 2nd hr	p > 0.9999	p = 0.62	p = 0.0003***	p ≤ 0.0001***
post-hoc vs 5 mg/kg	p < 0.0001***	p = 0.0006***	p = 0.041*	N/A
1st hr ictal events	49.3 ± 2.2	43.3 ± 3.0	46.2 ± 2.1	36.7 ± 3.1
2nd hr ictal events	36.42 ± 2.8	30.0 ± 3.0	27.0 ± 2.7	15.9 ± 2.3
2 way ANOVA: F3,174 = 1.169; P = 0.3229 post-hoc 1st hr vs 2nd hr	p = 0.0143*	p = 0.0275*	p ≤ 0.0001***	p ≤ 0.0001***
1st hr ictal duration	23.54 ± 1.27	27.31 ± 1.90	26.57 ± 1.51	28.35 ± 1.16
2nd hr ictal duration	31.41 ± 2.16	31.45 ± 2.31	26.03 ± 1.86	21.84 ± 2.81
2 way ANOVA: F3,174 = 5.161; P = 0.0019** post-hoc 1st hr vs 2nd hr	p = 0.0964	p > 0.9999	p > 0.9999	p = 0.4857
B) P10 seizure stats	+PB	0.5 mg/kg ANA12 + PB	2.5 mg/kg ANA12 + PB	5 mg/kg ANA12 + PB
1st hr seizure burden	711.8 ± 87.4	899.1 ± 86.4	758.3 ± 88.6	606.4 ± 62.7
2nd hr seizure burden	314.6 ± 53.1	198.2 ± 50.9	140.8 ± 43.2	54.6 ± 15.3
2 way ANOVA F3,82 = 1.903; P = 0.1356 post-hoc 1st vs 2nd hr	p = 0.0018**	p ≤ 0.0001***	p ≤ 0.0001***	p ≤ 0.0001***
1st hr ictal events	42.3 ± 5.1	46.7 ± 4.6	42.9 ± 4.4	33.7 ± 3.7
2nd hr ictal events	19.3 ± 2.7	13 ± 2.8	10.5 ± 3.3	4.0 ± 1.0
2 way ANOVA: F3,174 = 1.169; P = 0.3229 post-hoc 1st hr vs 2nd hr	p = 0.0011**	p ≤ 0.0001***	p ≤ 0.0001***	p ≤ 0.0001***
1st hr ictal duration	16.85 ± 0.75	21.69 ± 3.11	18.02 ± 1.79	18.20 ± 0.65
2nd hr ictal duration	15.91 ± 1.88	12.68 ± 2.58	13.53 ± 1.14	9.93 ± 1.99
2 way ANOVA: F3,174 = 5.161 P = 0.0019** post-hoc 1st hr vs 2nd hr	p > 0.9999	p = 0.0375*	p > 0.9999	p = 0.0867