Figure 4.

Convergence to a Common State at the Early Stages of Oligodendrocytes Lineage

(A and B) gt-SNE embedding of the three first stages of the oligodendrocytes lineage OPC, COP, and NFOL colored by cluster identity (A) and tissue of origin (B). Edges in (A) connect nodes between mutual neighbors (k = 150), but only if they are from different clusters.

(C) Gene expression of selected markers overlaid on gt-SNE embedding.

(D) Patterning transcription factor analysis. Circles represent fraction of positive cells in each cluster and brain region.

(E) Illustration of the proposed model of primary patterning, loss of regional identity and secondary diversification.