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. 2018 Aug 9;174(4):999–1014.e22. doi: 10.1016/j.cell.2018.06.021

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Figure S6 — Neurotransmitter Modularity, Related to Figure 7

(A) Co-expression of neurotransmitters. Rows and columns represent neurotransmitters. Circle size represents the number of cells in clusters with the indicated combination. Each circle shows (as a pie chart) the brain compartment in which we found the relevant clusters.

(B) Analysis of pan-markers along the different ranks of the taxonomy. The heatmap represents the percentage of clusters with trinarization score greater than 90% within the taxonomy unit. Rows represent taxonomy units and columns genes.

(C) Similar co-expression analysis as in (A) but with individual genes encoding neurotransmitters and neuropeptides. Upper half of the matrix shows pie charts representing only the compartment distribution. Lower part of the matrix represent the frequency each combination was found.

(D) Summary diagram of the biosynthesis components and transporters used to define neurotransmitter phenotypes. Asterisks indicate the genes used separately (glutamatergic neurons) or jointly (all other) to identify each class of neurotransmitter.