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. 2018 Jul 22;175(17):3435–3452. doi: 10.1111/bph.14357

Figure 4.

Figure 4

Visualization of drug effects in a hazard map. In each panel, orthogonal projections are shown with a 3D hazard map. (A) Concentration–block relationships of terfenadine, quinidine and amiodarone are shown as trajectories in a subspace at I Na,L block = 0% and I Ks block = 0%. (B) Concentration–block relationships of terfenadine, quinidine and amiodarone are shown as trajectories in a subspace at I Na,L block = 0% and I Ks block = 50%.