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. 2018 Jul 22;175(17):3435–3452. doi: 10.1111/bph.14357

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© 2018 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Visualizations of drug effects in hazard map. In each panel, orthogonal projections are shown with a 3D hazard map. (A) Concentration–block relationships of quinidine in a subspace at I _Na,L block = 0% and I _Ks block = 0% are shown. From the original trajectory (thick line), the effect of I _Ca,L block was added gradually to shift the trajectory (blue arrow). (B) The effect of I _Na,L block was visualized for quinidine and ranolazine in a subspace with I _Ca,L, I _Kr and I _Na,L coordinates (I _Na block = 0% and I _Ks block = 0%).