Figure 6.

Effects of multiple ionic current blocks on arrhythmogenicity and ECG indices. (A) In the five rows at the top, the extent of block of I _Kr, I _Ks, I _Ca,L, I _Na and I _Na,L is shown in colour. For each combination of ionic current block, the occurrence of arrhythmia is indicated in black (6th row). Prolongations of the QT interval (ΔQT, 7th row), J‐T_peak (ΔJ‐T_peak, 8th row) and T_peak‐T_end (ΔT_peak‐T_end, 9th row) are shown in colour. Colour codes are summarized in the bottom legend. (B) Coefficients of linear regression applied to changes in QT interval, T_peak‐T_end and J‐T_peak. (C) Coefficients of logistic regression applied to the relationship between the occurrence of arrhythmia and ionic current block.