Table 1.

Risk category of benchmark drugs

Drug name	CiPA risk (Gintant et al., 2016)	Redfern risk (Redfern et al., 2003)	CredibleMeds (Woosley et al. [http://www.CredibleMeds.org])	Prediction by database	Threshold concentration relative to ETPCunbound
Quinidine	High	1	Known risk of TdP	Arrhythmia	0.6
Dofetilide	High	1	Known risk of TdP	Arrhythmia	21.0
Bepridil	High	3	Known risk of TdP	Arrhythmia	7.9
dl‐Sotalol	High	1	Known risk of TdP	Arrhythmia	71
Terfenadine	Intermediate	2	Known risk of TdP	Arrhythmia	865.7
Ondansetron	Intermediate	–	Known risk of TdP	Arrhythmia	23.6
Cisapride	Intermediate	2	Known risk of TdP	Arrhythmia	13
Chlorpromazine	Intermediate	–	Known risk of TdP	Safe	–
Astemizole	Intermediate	2	Known TdP risk	Arrhythmia	182
Ranolazine	Low	–	Conditional risk of TdP	Safe	–
Verapamil	Low	5	–	Safe	–
Mexiletine	Low	–	–	Safe	–
Diltiazem	Low	5	–	Safe	–
Flecainide	–	3	Known risk of TdP	Arrhythmia	3.7
Nilotinib	–	–	Possible TdP risk	Arrhythmia	6.0
Cibenzoline	–	5	–	Arrhythmia	10.6
Sertindole	–	2	Possible TdP risk	Arrhythmia	27.2
Chloroquine	–	–	Known risk of TdP	Arrhythmia	172.4
Moxifloxacin	–	–	Known risk of TdP	Arrhythmia	73.3
Amiodarone	–	1	Known risk of TdP	Safe	–
Amitriptyline	–	4	–	Safe	–
Mibefradil	–	4	–	Safe	–
Propafenone	–	4	–	Safe	–
Quinine	–	–	Conditional risk of TdP	Safe	–
Ritonavir	–	–	Conditional risk of TdP	Safe	–
Saquinavir	–	–	Possible TdP risk	Safe	–

A total of 26 benchmark drugs are listed with their risk categories reported by three independent sources. Predictions made by the current hazard map are shown in columns 5 and 6 along with the threshold concentrations for arrhythmia occurrence. The IC₅₀ and Hill coefficient for each drug are listed in Supporting Information Table S2.1 with their sources.