Figure 2.

The effect of nafamostat mesylate (0.01–10 mg·kg⁻¹) and its vehicle (water for injection) on VMRs (n = 8 per group and n = 7 per group for 10 mg·kg⁻¹) and colonic compliance (n = 6 per group) in post‐colitis and control rats. The statistical analysis was performed on the complete dataset, but separate graphs were made for each dose for greater clarity. Thus, in rats post‐colitis, the effects of 0.01 mg·kg⁻¹ nafamostat are shown in A; 0.1 mg·kg⁻¹ in B, 1.0 mg·kg⁻¹ in C and 10 mg·kg⁻¹ in D. In E, 0.1 mg·kg⁻¹ of nafamostat was given to control rats, i.e. without colitis and did not change the VMR responses. In F, 0.1 mg·kg⁻¹ nafamostat did not change colonic compliance in either control or post‐colitis rats. Data are presented as mean ± SEM. *P < 0.05; significantly different from control + vehicle; ^# P < 0.05; significantly different from post‐colitis + vehicle; generalized estimating equations + least significant difference post hoc test.