Table 3.

Identification of liver metabolites via nanomate‐LTQ‐MS combined with multivariate analysis

No.	Metabolites	Identified ion (m/z)	VIP	Adduct	Fold‐changeb (PIO/Control)
1	CE 18:3	664.6	1.20	NH4+	0.77
2	CE 20:2	694.5	0.39	NH4+	1.09
3	CE 20:3	692.6	0.44	NH4+	1.07
4	CE 20:4	690.5	0.48	NH4+	1.10
5	CE 20:5	688.5	0.07	NH4+	0.99
6	DG 34:1	612.4	0.02	NH4+	1.00
7	DG 34:2	610.3	0.02	NH4+	1.00
8	DG 36:1	640.6	1.28	NH4+	1.25
9	PC 32:1	754.6	0.47	Na+	1.03
10	PC 32:2	752.6	0.29	Na+	0.97
11	PC 34:0	784.8	1.07	Na+	0.92
12	PC 34:1	782.7	0.62	Na+	0.95
13	PC 34:2	780.7	0.19	Na+	1.02
14	PC 34:3	778.6	0.06	Na+	1.00
15	PC 35:0	798.7	0.73	Na+	1.11
16	PC 36:0	790.7	1.49	H+	0.89
17	PC 36:1a	788.8	1.82	H+	0.86
18	PC 36:2a	786.7	1.87	H+	0.88
19	PC 36:3a	806.7	1.14	Na+	0.91
20	PC 36:4	804.7	0.30	Na+	0.95
21	PC 36:5	802.7	0.68	Na+	1.05
22	PC 38:5	808.7	0.72	H+	0.95
23	PC 38:2	814.8	0.96	H+	0.94
24	PC 38:3	812.8	0.88	H+	0.94
25	PC 38:4	810.7	1.02	H+	0.93
26	PC 38:6	828.7	0.58	Na+	0.90
27	PC 38:7	826.7	0.58	Na+	1.06
28	PC 40:2a	842.7	1.76	H+	1.17
29	PC 40:4a	860.7	2.30	Na+	1.39
30	PE 36:4a	762.8	2.36	Na+	0.86
31	PE 38:3	770.6	0.44	H+	0.96
32	PE 38:4	768.6	0.45	H+	0.95
33	PE 38:5	766.6	1.21	H+	0.91
34	PE 38:6a	764.5	2.04	H+	0.83
35	TG 42:0	740.5	0.08	NH4+	1.01
36	TG 46:0	796.7	0.09	NH4+	1.01
37	TG 46:1	794.7	1.41	NH4+	0.89
38	TG 46:2	792.6	1.30	NH4+	0.85
39	TG 48:0	824.7	0.06	NH4+	1.00
40	TG 48:1a	822.7	1.58	NH4+	1.27
41	TG 48:2	820.6	0.98	NH4+	1.27
42	TG 48:3	818.7	0.48	NH4+	1.03
43	TG 49:0a	838.8	1.63	NH4+	0.88
44	TG 49:1	836.7	0.84	NH4+	0.94
45	TG 49:2	834.7	0.57	NH4+	0.96
46	TG 50:0	852.8	1.41	NH4+	1.32
47	TG 50:1a	850.7	1.55	NH4+	1.42
48	TG 50:2a	848.7	2.17	NH4+	1.36
49	TG 50:3a	846.7	2.22	NH4+	1.69
50	TG 50:4a	844.6	1.53	NH4+	1.37
51	TG 51:1	864.7	1.32	NH4+	1.19
52	TG 52:0	880.8	1.00	NH4+	1.20
53	TG 52:1	878.8	0.98	NH4+	1.50
54	TG 52:2	876.7	1.07	NH4+	1.57
55	TG 52:3	874.7	1.14	NH4+	1.57
56	TG 52:4	872.7	1.12	NH4+	1.49
57	TG 52:5	870.7	1.44	NH4+	1.65
58	TG 53:1	892.7	1.40	NH4+	1.29
59	TG 53:2	890.7	1.50	NH4+	1.41
60	TG 53:3	888.7	1.34	NH4+	1.37
61	TG 53:4	886.6	1.45	NH4+	1.29
62	TG 54:3	902.7	0.81	NH4+	1.39
63	TG 54:4	900.7	0.80	NH4+	1.37
64	TG 54:5	898.7	0.78	NH4+	1.34
65	TG 54:6	896.7	0.88	NH4+	1.39
66	TG 55:0	922.7	0.50	NH4+	1.21
67	TG 55:1	920.7	0.61	NH4+	1.26
68	TG 55:2	918.7	0.86	NH4+	1.25
69	TG 55:3	916.7	0.71	NH4+	1.09
70	TG 55:4	914.7	0.90	NH4+	1.12
71	TG 55:5	912.7	1.21	NH4+	1.21
72	TG 56:1	934.7	0.10	NH4+	1.01
73	TG 56:3	930.7	0.19	NH4+	0.97
74	TG 56:4	928.8	0.64	NH4+	1.23
75	TG 56:6	924.7	0.48	NH4+	1.21
76	TG 57:2	946.7	0.11	NH4+	1.04
77	TG 57:3	944.6	0.16	NH4+	1.06
78	TG 57:4	942.7	0.10	NH4+	0.98
79	TG 58:5	954.8	0.03	NH4+	0.99
80	TG 58:6	952.7	0.02	NH4+	1.01

VIP, variable importance in the projection.

^aSignificantly different from OPLS‐DA models, based on VIP value (>0.7) and P <0.05.

^bRelative levels of metabolites were converted into fold‐change.