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. 2018 Jul 26;175(17):3594–3609. doi: 10.1111/bph.14428

Figure 5.

Figure 5

miR‐351‐5p aggravates oxidative stress by inhibiting Sirt6. (A) The expression of Sirt6 in IEC‐6 cells, rats and mice based on immunofluorescence staining (200× magnification, n = 5). (B) Levels of the proteins, Sirt6, AMPK, p‐AMPK, FoxO3α, p‐FoxO3α, MnSOD and catalase (CAT) in vitro and in vivo (n = 5). Data are presented as mean ± SD (n = 5).* P < 0.05, significantly different from control group. # P < 0.05, significantly different from 60 min reoxygenation or 90 min reperfusion group.