Table 1.

Clinical parameters of EAE in mice treated with IgG2a isotype control or anti-mCD52 antibody

	EAE onset (days after immunization)	Score at treatment onset	Disease duration before treatment	Final score	Score difference
Treatment at the peak of EAE
Isotype
n = 5	15.40 ± 1.40	2.75 ± 0.08	5.20 ± 1.83	2.15 ± 0.22	0.60 ± 0.15
Anti-mCD52
n = 4	20.25 ± 1.11	2.94 ± 0.36	2.75 ± 1.11	1.50 ± 0.54	1.44 ± 0.21
p value	0.02	0.83	0.37	0.32	0.02
Treatment after ~ 60 days of EAE
Isotype
n = 14	16.29 ± 0.85	2.61 ± 0.09	61.57 ± 1.27	2.43 ± 0.15	0.18 ± 0.10
Anti-mCD52
n = 18	15.28 ± 0.85	2.57 ± 0.11	61.72 ± 1.20	2.47 ± 0.13	0.10 ± 0.07
p value	0.29	0.59	0.95	0.85	0.47

All data are shown as mean values ± SEM. Mann-Whitney test was used to determine statistical significance