Table 2.
Biological processes, chromosomal location, and subcellular location of the 10 genes identified by the MCO and TSP method
| Gene name | Abbreviation | Biological Process | Subcellular location | Chromosomal location | Literature Review Expression | Expression due to our model | Reference |
|---|---|---|---|---|---|---|---|
| Ferritin light chain | FTL | iron homeostasis; neutrophil degranulation | cytosol, lysosome, extracellular exosome | 19q13.33 | Underexpression | overexpression | Uniprot [91] |
| Glial fibrillary acidic protein | GFAP | cytoskeletal organization, response to wounding, negative regulation of neuron projection development | cytoskeleton, cytosol, mitochondrion | 17q21.31 | Overexpression | overexpression | Gencards [92] |
| Heterogenous nuclear ribonucleoprotein A3 | HNRNPA3 | mRNA splicing, mRNA transport, RNA metabolic process | nucleus, cytosol | 2q31.2 | Underexpression | overexpression | Uniprot [93] |
| Cytochrome C oxidase subunit 1 | COX1 | aerobic respiration, aging, cerebellum development, response to electrical stimulus and oxidative stress | mitochondrion | 9q32-33.3 | Overexpression | overexpression | Uniprot [94] |
| NADH Ubiquinone oxidoreductase chain 2 | ND2 | receptor binding, reactive oxygen species metabolic process | mitochondrion inner membrane | Overexpression | overexpression | Uniprot | |
| NADH Uniquinone oxidoreductase chain 3 | ND3, SH3KBP1 | cellular response to glucocorticoid stimulus; oxidoreductase process, response to light intensity | mitochondrion inner membrane | 10p22.12 | Overexpression | overexpression | Uniprot [95, 96] |
| NADH Ubiquinone oxidoreductase chain 4 | ND4, DCAF6, hnnnrnp | aging, cerebellum process, mitochondrial electron transport | mitochondrion inner membrane | 1q24.2 | Overexpression | overexpression | Uniprot |
| Nuclear ubiquitine casein and cyclin dependent kinase substrate 1 | NUCKS1 | cellular glucose homeostasis, regulation of insulin receptor and regulation of viral transcription | nucleus | 1q32.1 | overexpression | overexpression | Uniprot [97] |
| 60S ribosomal protein 41 | RPL41 | rRNA processing, translation, viral transcription | cytosol | 12q13.2 | overexpression | overexpression | Uniprot, Genecards [98] |
| 40S ribosomal protein S10 | RPS10 | ribosomal small subunit | |||||
| assembly, rRNA processing, viral transcription | nucleus | 6p21.31 | overexpression | overexpression | Uniprot |