Table 3.
Brain regions showing statistically significant GM volumetric change
| Contrast | Distribution | Label | MNI coordinates | Cluster | Peak | ||
|---|---|---|---|---|---|---|---|
| x | y | z | Size | Z-score | |||
| UD >C | Cluster 1 | Right Frontal Medial Orbital | 9 | 50 | 33 | 401 | 4.24 |
| Right Anterior Cingulum | |||||||
| Cluster 2 | Right Insula | 47 | –2 | 8 | 211 | 3.95 | |
| SCD >UD | Cluster 1 | Vermis 4-5 | 6 | –48 | –18 | 102 | 3.44 |
| Vermis 3 | |||||||
| Main effect of informant reported decline (lower GM) | Cluster 1 | Left Hippocampus | –32 | –30 | –3 | 189 | 4.28 |
| Cluster 2 | Vermis 8 | 2 | –75 | –27 | 146 | 3.81 | |
| Left Cerebellum 8 | |||||||
| Cluster 3 | Left Cerebellum 7b | –32 | –80 | –38 | 433 | 3.64 | |
| Left Cerebellum Crus 2 | |||||||
Automated Anatomical Labeling (AAL) labels are used; MNI, Montreal Neurological Institute; UD, unaware decliner; C, controls; SCD, subjective cognitive decline.