Table 3.

Hazard ratios (HR) and 95% confidence intervals (95% C.I.) for Cox proportional hazard models predicting a first and multiple recurrences of bladder cancer, based on total fluid intake over the year after diagnosis, in 379 remaining NMIBC patients

	Model 1*			Model 2**			Model 3***
	n	Events	HR (95% C.I.)	p-value	HR (95% C.I.)	p-value	HR (95% C.I.)	p-value	p for trend
Time to first recurrence
250–850 mL	116	45	ref	ref	ref	0.65
850–1200 mL	124	48	1.08 (0.72–1.63)	0.71	1.04 (0.69–1.57)	0.86	1.07 (0.71–1.61)	0.76
>1200 mL	139	46	0.81 (0.54–1.21)	0.31	0.80 (0.53–1.20)	0.27	0.91 (0.60–1.37)	0.65
Time to multiple recurrences
250–850 mL	116	67	ref	ref	ref	0.53
850–1200 mL	124	71	1.07 (0.91–1.25)	0.41	1.06 (0.91–1.24)	0.43	1.08 (0.91–1.27)	0.38
>1200 mL	139	68	1.05 (0.87–1.26)	0.63	1.04 (0.86–1.26)	0.67	1.06 (0.89–1.26)	0.54

^*Model 1 is unadjusted, ^**Model 2 is adjusted for age, sex, and smoking status, ^***Model 3 is adjusted for age, sex, smoking status, tumour stage, grade, size and multiplicity. In the time to multiple recurrences analyses, Model 2 and Model 3 were additionally adjusted for the variable re-resection of a bladder tumour (second transurethral resection).