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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Virology. 2018 Jul 6;522:19–26. doi: 10.1016/j.virol.2018.06.017

Fig 3. CK1α controls HA-induced IFN receptor degradation, which regulates influenza viral replication and the host immunity to infection.

Fig 3.

During IAV infection, hemagglutinin induces activation of casein kinase 1α (CK1α), which mediates the phosphorylation and ubiquitination of IFNAR1 and IFNGR1, leading to the degradation of both receptors. The elimination of IFN receptors suppresses both the IFNAR-mediated anti-viral responses and the IFNGR-triggered host immunity to virus infection.