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. Author manuscript; available in PMC: 2019 Aug 7.
Published in final edited form as: Bioorg Med Chem. 2018 Jun 8;26(14):3909–3916. doi: 10.1016/j.bmc.2018.06.011

Fig. 3.

Fig. 3

In vivo antitumor activity of compound 12. Mean tumor weight-dose profiles in CAR xenograft nude mice (n = 6) following PO dosing of 12 at 25, 50 and 100 mg/kg/day. *P<0.05 compared with untreated control.