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. Author manuscript; available in PMC: 2019 Aug 7.
Published in final edited form as: Bioorg Med Chem. 2018 Jun 18;26(14):3925–3938. doi: 10.1016/j.bmc.2018.06.013

Fig. 2.

Fig. 2.

Compounds PL, 47, 49, and 48 abrogated the upregulation of OXR1 in WI-38 senescent cells induced by irradiation: (A) representative western blot analysis of OXR1 and β‐actin in WI‐38 normal or nonsenescent cells (NCs) and ionizing radiation-induced WI-38 senescent cells (IR‐SCs) 24 h after incubation with vehicle (Veh) or 5 µM of compound PL, 47, 49, or 48; (B) quantitative analysis of OXR1 levels in WI‐38 NCs and IR‐SCs 24 h after incubation with Veh or 5 µM of compound PL, 47, 49, or 48. Data in bar graphs are presented as mean ± SEM, n = 3, *p < 0.05 indicates significant difference comparing with IR-SCs with vehicle treatment.