TABLE 1: Association of clinical and immunological parameters with CD4 T-cell count.
Left panel: Selected regression parameter estimates with the three LASSO approaches implemented in the R packages grplasso, penalised and glmnet. Right panel: Standardized regression parameter estimates for the selected set of covariates by an un-regularized conventional generalized linear model using the R-function glm.
| LASSO | Generalized linear model | |||||
|---|---|---|---|---|---|---|
| Variable | grplasso | penalized | glmnet | Variable | Beta-coefficient | p-value |
| CD4 CD38+DR+ | −0.1701 | −0.1754 | −0.1718 | CD4 CD38+DR+ | −0.3123 | p<10−10 |
| CD4 Tem | −0.0549 | −0.0603 | −0.0567 | CD4Tem | −0.1630 | p<10−10 |
| Age at visit | −0.0632 | −0.0674 | −0.0646 | Age at visit | −0.1582 | p<10−10 |
| CD8 TnaTve | 0.1000 | 0.1008 | 0.1003 | CD8 TnaTve | 0.1105 | p<10−10 |
| sCD14 | −0.0472 | −0.0498 | −0.0481 | sCD14 | −0.1098 | p<10−10 |
| CD4 TnaTve | 0.1322 | 0.1274 | 0.1305 | CD4 TnaTve | 0.0475 | p=0.0147 |
| iFABP | 0 | 0 | 0 | - | - | - |
| CD8 CD38+DR+ | 0 | 0 | 0 | - | - | - |
| CD8 Tem | 0 | 0 | 0 | - | - | - |
| Sex | 0 | 0 | 0 | - | - | - |
| Viral load | 0 | 0 | 0 | - | - | - |
| CD4 PD1 | 0 | 0 | 0 | - | - | - |
| CD8 PD1 | 0 | 0 | 0 | - | - | - |
| Gag CD4 IFNg | 0 | 0 | 0 | - | - | - |
| Gag CD4 IL2 | 0 | 0 | 0 | - | - | - |
| Gag CD8 IFNg | 0 | 0 | 0 | - | - | - |
| Gag CD8 IL2 | 0 | 0 | 0 | - | - | - |