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. 2018 Jul 29;2018:6126413. doi: 10.1155/2018/6126413

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Copyright © 2018 Da Yeon Lee et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Reduced inflammatory response in LPS-stimulated microglia cocultured with rat bone marrow-derived mesenchymal stem cells (rBM-MSCs). (a) Gene network related to inflammatory response was constructed, and cellular function was predicted algorithmically using Ingenuity Pathway Analysis. Red and green areas indicate up- and downregulated genes, respectively. Differentially expressed genes were obtained from microarray data (>1.2 fold-change). (b) Quantitative real-time PCR analysis of gene expression-related inflammation in LPS-stimulated microglia cocultured with rBM-MSCs compared to control (microglia only). (c) Activated microglia were counted in light microscopy images and quantified as the percentage of activated microglia/total cell number. Cells at the edge of the images were not counted. Scale bar: 20 μm. ^∗ p < 0.05 and ^∗∗ p < 0.01 versus control (microglia only).