Table 6.
Week | db/+ | db/db | 0.1 g/kg Met | 0.2 g/kg TM | 0.4 g/kg TM | |
---|---|---|---|---|---|---|
Body weights (g) | 1 | 20.2 ± 0.4 | 43.2 ± 0.4### | 42.9 ± 0.8 | 43.3 ± 0.8 | 43.6 ± 0.7 |
3 | 21.4 ± 0.4 | 45.0 ± 0.7### | 44.8 ± 0.7 | 46.5 ± 0.8 | 44.8 ± 0.7 | |
5 | 20.9 ± 0.4 | 48.0 ± 1.1### | 43.9 ± 0.9∗ | 45.3 ± 1.2 | 43.6 ± 0.8∗ | |
7 | 21.7 ± 0.3 | 51.7 ± 1.0### | 47.5 ± 1.2∗ | 50.2 ± 1.3 | 47.6 ± 0.8∗ | |
9 | 21.1 ± 0.7 | 55.7 ± 0.9### | 52.9 ± 0.4∗ | 52.8 ± 1.4 | 49.5 ± 1.2∗∗ | |
| ||||||
Plasma glucose (mmol/L) | 1 | 5.6 ± 0.4 | 19.1 ± 1.4### | 19.6 ± 1.2 | 17.4 ± 0.9 | 18.8 ± 2.1 |
3 | 6.9 ± 0.4 | 19.6 ± 1.5### | 18.8 ± 1.8 | 17.2 ± 0.9 | 18.8 ± 2.3 | |
5 | 6.5 ± 0.3 | 18.8 ± 1.2### | 16.6 ± 1.1 | 15.8 ± 1.0 | 16.0 ± 1.5 | |
7 | 6.6 ± 0.4 | 21.7 ± 1.2### | 16.8 ± 1.2∗ | 12.9 ± 1.2∗∗ | 15.1 ± 1.6∗ | |
9 | 6.5 ± 0.5 | 21.3 ± 1.1### | 13.8 ± 1.5∗ | 14.0 ± 1.2∗ | 13.7 ± 1.7∗ | |
| ||||||
Organ indexes (%) | Spleen | 0.32 ± 0.06 | 0.11 ± 0.01### | 0.13 ± 0.01∗∗ | 0.15 ± 0.02∗∗ | 0.17 ± 0.02∗∗∗ |
Kidney | 1.27 ± 0.07 | 0.70 ± 0.07### | 0.79 ± 0.08∗ | 0.73 ± 0.07 | 0.84 ± 0.13∗ |
The data were analyzed using a one-way ANOVA and they are expressed as means ± SEMs (n = 10). ###p < 0.001 versus db/+ mice; ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001 versus nontreated db/db mice. TM: T. melanosporum.