Skip to main content
. 2001 Nov 6;98(23):13361–13366. doi: 10.1073/pnas.231487398

Figure 5.

Figure 5

Aneuploid cells in the adult cortex are neurons. (A) The presence of both MAP2-positive (large arrow) and MAP2-negative (small arrows) cells in a 10 μm section through adult cerebral cortex demonstrates the specificity of MAP2 labeling (red). Nuclei were counterstained with DAPI (blue). (B–G) Cells in 10 μm sections through the adult male cortex were hybridized with X (red) and Y (green) chromosome paints (B, D, and F). Cells in these same 10 μm sections were then immunostained for MAP2 (C, E, and G). (B and C) The cell on the left contains both an X and a Y chromosome, whereas the cell on the right has an extra Y chromosome (B). The cell with 2 Y chromosomes is MAP2-positive (C). These cells are in visual cortex. (D and E) A cell in motor cortex contains an extra X chromosome (D) and is MAP2-positive (E). (F and G) A cell in motor cortex contains an extra Y chromosome (F) and is MAP2-positive (G). [Bars = 10 μm (A and C) and 5 μm (E and G).]