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Multipotentiality of human stromal (mesenchymal) stem cells (MSC). Under proper conditions, MSCs can form (a) bone when implanted subcutaneously in immune deficient mouse coupled with hydroxyapatite/tricalicum phosphate (HA/TCP) as carrier, (b) cartilage when cells cultured in vitro as cell aggregates in presence of transforming growth factor B or (c) fat when treated in vitro with insulin, dexamethasone and rosiglitazone.
