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. 2018 Aug 13;7:23. doi: 10.1186/s40169-018-0202-9

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — A hypothetical model for YAP/TAZ regulation by tension at FAs. a Low tension FA with small actomyosin force and/or soft ECM. b High tension FA with large actomyosin force and stiff ECM. FA tension induces sequential phosphorylation (P) of FAK, Src and p130Cas (Cas). Phosphorylated Src activates the PI3K–PDK2 pathway, whilst the phosphorylated p130Cas activates the Rac1–PAK pathway. Activation of these pathways inhibits LATS-mediated phosphorylation of YAP, facilitating nuclear translocation of YAP