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. 2018 Aug 13;7:23. doi: 10.1186/s40169-018-0202-9

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — A hypothetical model for YAP/TAZ regulation by tension at AJs. a Low tension AJ with small actomyosin force. Under this condition, Merlin localizes to AJs through its binding with α-catenin. b High tension AJ with large actomyosin force. AJ tension causes dissociation of Merlin from AJs, which may be associated with a force-induced conformational change of α-catenin. Released Merlin enters the nucleus, binds nuclear YAP, and then exports it from the nucleus with the aid of NESs in Merlin