Table 2.
Association between prenatal folate status and child wheeze at age 3 years
| Current wheeze in the 3rd year of life | ||
|---|---|---|
|
| ||
| Unadjusted OR [95% CI] | Adjusted OR [95% CI]1 | |
| 2nd trimester (n= 843) | ||
| Maternal plasma folate level (10 ng/ml)2 | 0.91 [0.80, 1.05] | 0.97 [0.84, 1.12] |
|
| ||
| 2nd trimester | ||
| Maternal plasma folate level | ||
| < 20 ng/ml (n= 335) | 1.00 (ref) | 1.00 (ref) |
| ≥ 20 ng/ml3 (n= 508) | 0.61 [0.43, 0.85]** | 0.67 [0.46, 0.97]* |
|
| ||
| 3rd trimester (n= 809) | ||
| Maternal plasma folate level (10 ng/ml)2 | 0.91 [0.78, 1.05] | 1.01 [0.86, 1.18] |
|
| ||
| 3rd trimester | ||
| Maternal plasma folate level | ||
| < 20 ng/ml (n= 293) | 1.00 (ref) | 1.00 (ref) |
| ≥ 20 ng/ml3 (n= 516) | 0.73 [0.51, 1.04] | 0.91 [0.62, 1.34] |
1
Models adjusted for maternal age, race, education, parity, smoking during pregnancy, asthma history, pre-pregnancy BMI, 2nd trimester plasma vitamin D level, delivery route, and child sex and birth weight
2
Plasma folate concentrations entered as a continuous measure; expressed as 10 ng/ml increment
3
Considered as higher than physiologically relevant level of plasma folate
OR and 95% CI indicate Odds Ratio and 95% Confidence Interval
1 ng/mL = ~2.3 nmol/L
*
P< 0.05
**
P< 0.01