Table 3.
Prenatal folate status and atopic dermatitis at 3 years of age
| Atopic dermatitis at age 3 years | ||
|---|---|---|
|
| ||
| Unadjusted OR [95% CI] | Adjusted OR [95% CI]1 | |
| 2nd trimester (n= 851) | ||
| Maternal plasma folate level (10 ng/ml)2 | 0.96 [0.85, 1.09] | 1.04 [0.92, 1.19] |
|
| ||
| 2nd trimester | ||
| Maternal plasma folate level | ||
| < 20 ng/ml (n= 339) | 1.00 (ref) | 1.00 (ref) |
| ≥ 20 ng/ml3 (n= 512) | 0.92 [0.67, 1.26] | 1.19 [0.85, 1.68] |
|
| ||
| 3rd trimester (n= 817) | ||
| Maternal plasma folate level (10 ng/ml)2 | 0.82 [0.97, 0.99]** | 0.87 [0.75, 1.01] |
|
| ||
| 3rd trimester | ||
| Maternal plasma folate level | ||
| < 20 ng/ml (n= 297) | 1.00 (ref) | 1.00 (ref) |
| ≥ 20 ng/ml3 (n= 520) | 0.71 [0.52, 0.98]* | 0.84 [0.59, 1.18] |
1
Models adjusted for maternal age, race, education, parity, smoking during pregnancy, asthma history, pre-pregnancy BMI, 2nd trimester plasma vitamin D level, delivery route, and child sex and birth weight
2
Plasma folate concentrations entered as a continuous measure; expressed as 10 ng/ml increment
3
Considered as higher than physiologically relevant level of plasma folate
OR and 95% CI indicate Odds Ratio and 95% Confidence Interval
1 ng/mL = ~2.3 nmol/L
*
P< 0.05
**
P< 0.01