Table 1.

No differences in selected in vivo characteristics

	Wild Type		β-Actin KO
	Young Adult (8–13 wk old)	Mature Adult (18–23 wk old)	Young Adult (8–13 wk old)	Mature Adult (18–23 wk old)
Male
Body weight, g	27.3 ± 0.61	33.0 ± 0.98	27.0 ± 0.46	33.1 ± 0.49
MRI - fat mass, g	2.42 ± 0.16	4.13 ± 0.56	2.16 ± 0.15	3.75 ± 0.36
MRI - lean mass, g	23.8 ± 0.52	28.1 ± 0.52	23.7 ± 0.51	28.4 ± 0.46
Blood glucose, mmol/l	15.5 ± 1.24	17.0 ± 1.47	17.1 ± 0.86	16.9 ± 0.82
Insulin, ng/ml	0.59 ± 0.05	1.31 ± 0.29	0.60 ± 0.05	1.25 ± 0.17
Max running test, stop speed, m/s	0.59 ± 0.02	0.56 ± 0.01	0.60 ± 0.02	0.57 ± 0.02
Female
Body weight, g	20.1 ± 0.30	28.3 ± 0.97	20.3 ± 0.24	27.6 ± 0.58
MRI - fat mass, g	2.06 ± 0.12	5.33 ± 0.59	1.97 ± 0.11	5.01 ± 0.62
MRI - lean mass, g	17.1 ± 0.27	22.3 ± 0.43	16.9 ± 0.28	22.0 ± 0.27
Blood glucose, mmol/l	15.5 ± 1.72	15.6 ± 1.11	13.9 ± 0.76	17.8 ± 1.52
Insulin, ng/ml	0.45 ± 0.01	0.71 ± 0.08	0.55 ± 0.04	0.73 ± 0.05
Max running test, stop speed, m/s	0.55 ± 0.01	0.56 ± 0.02	0.54 ± 0.02	0.56 ± 0.02

All values are shown as means ± SE. Mice were injected with 2 g/kg body wt d-glucose for the intraperitoneal glucose tolerancew test. Blood glucose values are measured 20 min post-glucose injection together with a 50-µl blood sample to measure insulin levels. Young adult mice: 8–13 wk old, mature adult mice: 18–23 wk old; n = 9–10 mice.