Table 1.

Animal characteristics of WT mice following 2 wk of systemic IL-6 overexpression

	WT
	Vector	IL-6
No. of mice	17	16
Body weight, g
Pre	24.8 ± 0.3	25.0 ± 0.4
Post	26.0 ± 0.2*	25.7 ± 0.4*
%Change from Pre	4.7 ± 0.9	2.8 ± 0.5
Tibialis anterior, mg	47 ± 0.8	46 ± 0.9
Epididymal fat, mg	291 ± 11	286 ± 15
Spleen, mg	80 ± 6	132 ± 4†
Testes, mg	192 ± 5	202 ± 5
LABC, mg	86 ± 2	82 ± 2
Seminal vesicle, mg	247 ± 9	240 ± 10
Plasma IL-6, pg/ml	0 ± 0	156 ± 24†
Food intake, g/day	3.7 ± 0.1	3.6 ± 0.1
Tibia length, mm	16.9 ± 0.1	16.9 ± 0.1

Data are means ± SE. A two-way ANOVA (IL-6 × time) was used to determine differences in body weight over time. Student’s t-test was performed to determine difference between all other variables. Statistical significance was set at P < 0.05. WT, wild type; LABC, levator ani/bulbocavernosus muscle.

^*Main effect of post time point;

^†different from Vector.