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. 2018 Aug 6;9:865. doi: 10.3389/fphar.2018.00865

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Copyright © 2018 Diezmos, Markus, Perera, Gan, Zhang, Sandow, Bertrand and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of mucosal damage in the cytokine-induced colitis model. Average area of structural damage from each tissue was measured and analyzed using one-way ANOVA followed by Holm–Sidak’s multiple comparison tests. Crypt damage in TNFα and IL-1β (each 10 ng/mL) treated mucosa was highly significant compared to the incubation-control group (^∗∗∗∗P < 0.0001). Cytokines-induced damage was reduced in the presence of either ¹⁰Panx1 (^∗P = 0.0224) or A438079 (^∗P = 0.0224), and in the presence of both inhibitors (^∗P = 0.0422).