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. 2018 Aug 6;9:865. doi: 10.3389/fphar.2018.00865

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Copyright © 2018 Diezmos, Markus, Perera, Gan, Zhang, Sandow, Bertrand and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Images of CD45-IR leukocytes (top panels) and IBA1-IR macrophages and monocytes (bottom panels) in cytokines-induced colitis model from a representative human colon specimen. CD45-IR leukocytes (A–D) are densely and IBA1-IR macrophages (E–H) moderately localized in the lamina propria area. Note, in the TNFα and IL-1β treatment tissues, CD45-IR leukocytes migrated to the damaged crypts (indicated by ^∗ in B) and more IBA1-IR macrophages were found aligning the damaged epithelium (indicated by ^∗ in F). The scale bar represents 50 μm. C, crypt; Epi, epithelium; LP, lamina propria. All images were taken from the colonic mucosa of a 50-year-old female patient.