FIGURE 1.

Palmitate (PA)-enriched diet exhibit increases α-syn expression in B6D2 mice. Representative western blot (A) and optical density (B) of α-syn in the substantia nigra-enriched fraction of brains from B6D2 mice showing that the PA diet significantly increases α-syn protein levels. (C) Real-time RT-PCR shows that the PA diet increases SNCA mRNA. Immunocytochemistry of the substantia nigra shows that the PA diet-fed mice exhibit increased α-syn immunoreactivity (E) compared to the control diet (D). ^∗p < 0.05, ^∗∗p < 0.01 versus control diet.