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. 2018 Aug 6;9:1757. doi: 10.3389/fmicb.2018.01757

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Copyright © 2018 Apopa, Alley, Penney, Arnaoutakis, Steliga, Jeffus, Bircan, Gopalan, Jin, Patumcharoenpol, Jenjaroenpun, Wongsurawat, Shah, Boysen, Ussery, Nookaew, Fagan, Bebek and Orloff.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The diversity of lung microbiome derived from a normal cell and tumor cell of Non-small cell lung cancer (NSCLC) of the two subtypes adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC). (A) The average of the phylum level pie chart of all lung samples in this study (N = 22). (B) Phylum level distribution (relative abundance) of microbial communities comparing paired normal (N = 8), LUAD (N = 7), and LUSC (N = 7) lung tissue patients (total N = 22). Each bar represents a fraction of the bacteria detected in a given sample. (C) Alpha diversity plot of the three groups of samples (normal, LUAD and LUSC) by observed and Chao1 model. The statistical comparisons of mean among the group were reported as p-values derived from Mann-Whitney test.