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. 2018 Aug 6;9:757. doi: 10.3389/fphar.2018.00757

FIGURE 2.

FIGURE 2

Effect of chlorogenic acid on behavioral parameters. (A) Rotarod test of mice was performed after 7 days from MPTP intoxication in control and MPTP groups. The time on the rotarod was found to be decreased in MPTP-intoxicated group compared with control. (B) After the completion of dosing, a significant improvement in the time of stay on rotarod was found in CGA-treated mice compared with the MPTP-intoxicated group. MPTP group shows reduced time of walking and staying on rotarod compared with the control group. (C) Hanging test was performed after 7 days from MPTP intoxication in control and MPTP groups. The hanging time was found to be reduced in MPTP-intoxicated groups compared with control. (D) After the completion of dosing, a significant improvement in the hanging time was observed in the CGA-treated group compared with the MPTP-treated group. MPTP group mice fall early compared with the control group. (E) Narrow beam walking test was performed after 7 days from MPTP intoxication in control and MPTP groups. The narrow beam walking time was found to be increased in MPTP-intoxicated groups compared with control. (F) In contrast, CGA treatment declines the walking time against MPTP-induced phenotype in mouse after the completion of dosing. Data are expressed in terms of mean ± SEM (n = 6), ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001. CGA, chlorogenic acid; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, SEM, standard error of mean.