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. 2018 Aug 6;9:757. doi: 10.3389/fphar.2018.00757

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Copyright © 2018 Singh, Rai, Birla, Zahra, Kumar, Gedda, Tiwari, Patnaik, Singh and Singh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemistry of tyrosine hydroxylase in the SN and striatum of mice. With 10 × magnifications after staining. The expression of TH and nerve terminal density were significantly decreased in the SN and ST of MPTP-injected mice compared with the control group, whereas the expression of TH significantly increased in CGA-treated group compared with MPTP-injected mice. Values are expressed as mean ± SEM (n = 3). ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001. CGA, chlorogenic acid; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; SN, substantia nigra; TH, tyrosine hydroxylase; ST, striatum; SEM, standard error of mean; IFV, integrated fluorescent value.