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Time course of changes in secreted protein acidic and rich in cysteine (SPARC) expression in response to the imposition of left ventricular (LV) pressure overload (PO). Immunoblot analysis of SPARC showed that levels were significantly increased at 1 wk of LV PO and remained increased at 4 wk of LV PO. Values are means ± SE. *P < 0.05 vs. control (no LV PO).
