Table 1.
Echocardiographic characterization of LV structure and function of mice at baseline and at 3 days, 1 wk, 2 wk, and 4 wk of LV PO
| LV PO |
|||||
|---|---|---|---|---|---|
| Baseline Control | 3 day | 1 wk | 2 wk | 4 wk | |
| Heart rate, beats/min | 510 ± 29 | 508 ± 27 | 488 ± 61 | 486 ± 34 | 522 ± 45 |
| LV ejection fraction, % | 62 ± 3 | 61 ± 4 | 57 ± 5 | 58 ± 8 | 56 ± 9 |
| LV mass/body mass, mg/g | 3.4 ± 0.1 | 3.7 ± 0.2 | 4.1 ± 1.1 | 5.7 ± 0.3* | 6.1 ± 1.0* |
| LV mass/tibia length, mg/mm | 4.2 ± 0.5 | 4.7 ± 0.7 | 5.6 ± 1.1 | 7.0 ± 0.9* | 8.7 ± 1.0* |
| LV end-diastolic volume/tibia length, ml/mm | 3.0 ± 0.4 | 2.8 ± 0.4 | 3.2 ± 0.5 | 3.4 ± 0.8 | 3.3 ± 0.9 |
| Left atrial dimension/tibia length, mm/mm | 0.10 ± 0.01 | 0.10 ± 0.03 | 0.12 ± 0.02 | 0.19 ± 0.04* | 0.20 ± 0.03* |
Values are means ± SD. Left ventricular (LV) ejection fraction was calculated as follows: (end-diastolic volume − end-systolic volume)/end-diastolic volume × 100. PO, pressure overload.
*
P < 0.05 vs. baseline control.