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Ataxia telangiectasia mutated kinase increases aggresome accumulation in the left ventricle (LV) during 4 h of myocardial infarction (MI). Left: proteostat dye-stained images obtained from the LV of wild-type (WT) and heterozygous knockout (hKO) hearts 4 h after MI. Left: red fluorescent staining indicates aggresomes. Right: quantitative analysis of aggresomes in the LV region. n = 3. *P < 0.05 vs. the respective sham group; #P < 0.05 vs. the WT-MI group.
