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Ablation of the PKC-δ isoform eliminates α-ketoglutarate (α-KG)-stimulated Cl− absorption (JCl). Cortical collecting ducts (CCDs) from PKC-δ (n = 3) and their wild-type littermates (n = 4) were perfused in vitro in the presence and absence of α-KG in the luminal fluid. As shown, PKC-δ gene ablation eliminated the increase in Cl− absorption observed with α-KG application to the perfusate. Squares indicate means ± SE under each condition.
