Renin mRNA levels. A: graph of renin mRNA levels normalized to 18S ribosomal RNA at D0 in young (n = 21) and aged mice (n = 23), relative to young mice at D0. B: graph of renin mRNA levels normalized to 18S ribosomal RNA at D0 and D25 in water (n = 4 in young, n = 6 in aged), hydralazine (n = 6 in young, n = 4 in aged), enalapril (n = 6 in young, n = 6 in aged), and losartan (n = 5 in young, n = 7 in aged) treatment group, relative to young water group mice at D0.