Fig. 2.

Effect of let-7b on HCC cell growth. (A) HepG2 were infected with MOIs let-7b lentivirus or VC at MOI 50. Let-7b expression level was determined by qRT-PCR. Data are expressed as the fold change relative to HepG2 cells without infection. ^*p < 0.05 vs BC; ^**p < 0.05 vs VC; (B) The cell growth curves showed the let-7b significantly inhibits HepG2 cell growth after day 2. ^*p < 0.05 vs BC; ^**p < 0.05 vs VC; (C) let-7b reduced the number of HepG2 colonies. However, anti-let-7b increased the number of HepG2 colonies; (D) Loss of let-7b promoted the HepG2 cell growth, especially after day 2. Results are mean ± SD (n = 3); ^*p < 0.05 vs BC; ^**p < 0.05 vs VC.