Table 2.
Association of candidate genes with MRI markers of CMA and/or HT
| Gene | Polymorphism | Association | |
|---|---|---|---|
| MRI markers of CMA | HT | ||
| AGT | rs699 | Lacunes [35, 41], WMH [41] Loss of white matter tract microstructure [46] Not verified [42, 45] |
Found [37, 8] Not verified [39, 40] |
| AGT | rs4762 | Not verified [42] | Found [37, 38] Not verified [39, 40] |
| AGT | –20A > C | WMH [45] | Found [45] |
| ACE | I/D Alu-sequences | Alu-sequences WMH [52–55] Not verified [46] | Found [47-52] |
| CYP11B2 | rs1799998 | WMH, expansion of perivascular spaces [36, 56] | No data |
| NOS1 | rs3782218 | Contradictory data | Found [59] |
| NOS3 | rs3918226 | Contradictory data | Found [59] |
| NOS3 | rs3918227 | Contradictory data | Found [59] |
| EDN1 | rs5370 | Not verified [45] | Found [63, 64] |
| MTHFR | rs1801133 | WMH, LI [65, 66] Not verified [55, 67, 68] |
Found [65, 66] |
| PLAT | rs2020918 | LI [71, 72] | No data |
| FGB | rs1800790 | LI [73] | No data |
| IL1B | rs16944 | LI [78], WMH [81] | No data |
| IL6 | rs1800795 | LI [79], WMH [80] | Not verified [74] |
| IL6 | rs1800796 | LI [80] | Found [75] |
| TNFA | rs1800629 | No data | Found [75] |
| MMP2 | rs243865 | WMH [85] | No data |
| MMP2 | rs1030868 rs2241145 rs2287074 rs2287076 rs7201 |
WMH [84] | No data |
| MMP9 | rs3918242 | No data | Found [78] |
| CRP | rs3091244 | WMH [81] | No data |
| VEGF | rs2010963 | LI [86] | Found [86] |
| BDNF | rs6265 | WMH [87] | No data |