Table 3.

Results of genome-wide association studies (GWAS) for HT and CMA

Study	Single nucleotide polymorphism	Locus	P-value
			Systolic BP	Diastolic BP
HT
Global BPGen (Global Blood Pressure Genetics) [89] Sample size – 34,433 individuals	rs17367504 rs11191548 rs12946454 rs16998073 rs1530440 rs653178 rs1378942 rs16948048	1p36* 10q24* 17q21 4q21 10q21 12q24* 15q24* 17q21	1 × 10-5 3 × 10-17 4 × 10-6	7 × 10-9 3 × 10-6 1 × 10-7 6 × 10-8 5 × 10-6
CHARGE (The Cohorts for Heart and Ageing Research in Genome Epidemiology) [90] Sample size – 29,136 individuals	rs1004467 rs381815 rs2681492 rs2681472 rs3184504 rs9815354 rs11014166 rs2384550 rs6495122	10q24* 11p15 12q21 12q21 12q24 3p22 10p12 12q24* 15q24*	1.99 × 10-6 5.76 × 10-7 3.01 × 10-11 5.73 × 10-7	3.74 × 10-8 1.68 × 10-8 7.88 × 10-7 8.82 × 10-7 1.32× 10-7 8.10 × 10-7
ICBP GWAS (International Consortium for Blood Pressure Genome-Wide Association Studies) [91] Sample size – 200,000 individuals	rs2932538 rs13082711 rs419076 rs13107325 rs13139571 rs1173771 rs11953630 rs1799945 rs805303 rs4373814 rs932764 rs7129220 rs633185 rs2521501 rs17608766 rs1327235 rs6015450 rs17367504 rs3774372 rs1458038 rs1813353 rs4590817 rs11191548 rs381815 rs17249754 rs3184504 rs10850411 rs1378942 rs12940887	1p13 3p24 3q26 4q24 4q32 5p13 5q33 6p22 6p21 10p12 10q23 11p15* 11q22 15q26 17q21 20p12 20q13 1p36* 3p22* 4q21 10p12 10q21* 10q24 11p15* 12q21 12q24* 12q24* 12q24* 17q21*	1.2 × 10-9 1.5 ×10-6 1.8 × 10-13 3.3 × 10-14 1.2 × 10-6 1.8 ×10×-16 3.0 × 10-11 7.7 × 10-12 1.5 × 10-11 4.8 × 10-11 7.1 × 10-16 3.0 × 10-12 1.2 × 10-17 5.2 × 10-19 1.1 × 10-10 1.9 × 10-8 3.9 × 10-23 8.7 × 10-22 0.39 1.5 × 10-23 2.6 × 10-12 4.0 × 10-12 6.9 × 10-26 5.3 × 10-11 1.8 × 10-18 3.8 × 10-18 5.4 × 10-8 5.7 ×10-23 1.8 × 10-10	9.9 × 10-10 3.8 × 10-9 2.1 × 10-12 2.3 × 10-17 2.2 × 10-10 9.1 × 10-12 3.8 × 10-11 1.5 × 10-15 3.0 × 10-11 4.4 × 10-10 8.1 × 10-7 6.4 × 10-8 2.0 × 10-15 1.9 × 10-15 0.017 1.4 × 10-15 5.6 × 10-23 3.5 × 10-19 9.0 × 10-14 8.5 × 10-25 2.3 × 10-15 1.3 × 10-12 9.4 × 10-13 5.3 × 10-10 1.2 × 10-14 3.6 × 10-25 5.4 × 10-10 2.7 × 10-26 2.3 × 10-14
WMH
CHARGE (The Cohorts for Heart and Ageing Research in Genome Epidemiology) [92] Sample size – 9,361 individuals	rs3744028 rs1055129 rs3744017 rs936393 rs9894383 rs11869977	17q25	4.0 × 10-9 4.1 × 10-8 7.3 × 10-9 6.8 × 10-9 5.3 × 10-9 5.7 × 10-9
Multi-ethnic GWAS [96] Sample size – 21,079 individuals	rs72848980 rs7894407 rs7214628 rs12357919 rs7909791 rs78857879 rs2984613 rs11679640	17q25* 17q25* 17q25 10q24.33 10q24.33 2p16.1 1q22 2p21	2.6 × 10-9 2.6 × 10-8 5.1 × 10-9 1.5 × 10-8 2.9 × 10-9 1.5 × 10-8 2.0 × 10-8 2.1 × 10-6

^*Loci identified in different studies.