| National Survey of Family Growth (NSFG) |
1973 |
Centers for Disease Control (CDC) |
https://www.cdc.gov/nchs/nsfg/index.htm |
Well-validated survey since 1973; nationally representative for ages 15–49; inclusion of male participants since 2002; approximately 5,000 interviews per year; assesses issues of pregnancy, fertility, contraception, general & reproductive health; over 600 journal articles published using NSFG |
Originally designed for female respondents; limited scope related to infertility; limited information available for male infertility |
| Reproductive Medicine Network (RMN) |
1989 |
Eunice Kennedy Shriver National Institute of Child Health & Human Development—NIH |
https://www.nichd.nih.gov/research/supported/Pages/rmn.aspx |
Designed to perform multi-center clinical trials; landmark papers have been published related to male infertility from RMN trials; over 50 publications since 1990; data can be linked to biologic specimens |
Poor recruitment for male trials; majority of focus is on female infertility; failed varicocelectomy trial; not specifically designed for male infertility |
| Andrology Research Consortium (ARC) |
2013 |
Society for the Study of Male Reproduction (SSMR) |
http://ssmr.org/about/welcome.aspx |
Prospective questionnaire data; 14 different centers specializing in male infertility; specifically designed for male infertility; supported by SSMR; female fertility data available |
Limited availability of biologic specimens; requires clinician involvement to ensure ongoing enrollment & completion of questionnaires; no significant publications to date; relatively small patient size compared to other databases (approximately 2,000) |
| Truven Health MarketScan®
|
1988 |
Truven Health Analytics—IBM |
https://truvenhealth.com/markets/life-sciences/products/data-tools/marketscan-databases |
Over 240 million patients included; population-level data; all claims included in data set; ability to link infertility parameters to other health issues |
Retrospective data; limited ability to link male & female partners; not specifically designed for male infertility |
| Utah Population Database (UPDB) |
1987 |
University of Utah |
https://healthcare.utah.edu/huntsmancancerinstitute/research/updb/ |
Information on >8 million individuals in Utah; data linked to >100 million family members; 85% of Utah medical records included in UPDB; 6 generations of pedigree data; biologic specimens available |
Retrospective data; not representative of US population; not specifically designed for male infertility |
| The Hutterites & Ober Lab |
1994 |
University of Chicago |
http://ober.bsd.uchicago.edu/ |
14-generation pedigree data available; fertility profiles obtained for nearly 300 couples; whole genome genetic data available; data available for males and females |
Not representative of US population; founder population; not specifically designed for male infertility |
