Table 6. Toxicity profile of standard and modified FOLFIRINOX.
| Event | Toxicity, n (%) | P | |
|---|---|---|---|
| Standard FOLFIRINOX$ (N=59) | Modified FOLFIRINOX (N=44) | ||
| Any G3–4 toxicity | 21 (35.6) | 16 (36.4) | 1.00 |
| Non-hematologic toxicity | |||
| Nausea | 2 (3.4) | 1 (2.3) | 1.00 |
| Vomiting | 2 (3.4) | 1 (2.3) | 1.00 |
| Constipation | 0 (0.0) | 2 (4.5) | 0.18 |
| Diarrhea | 1 (1.7) | 2 (4.5) | 0.57 |
| Mucositis | 2 (3.6) | 1 (2.3) | 1.00 |
| Fatigue | 4 (6.8) | 1 (2.3) | 0.38 |
| Decreased appetite | 1 (1.7) | 0 (0.0) | 1.00 |
| Peripheral neuropathy | 4 (6.9) | 2 (4.5) | 1.00 |
| Hematologic toxicity | |||
| Anemia | 3 (5.1) | 3 (6.8) | 1.00 |
| Leukopenia | 1 (1.7) | 4 (9.1) | 0.16 |
| Neutropenia | 9 (15.3) | 7 (15.9) | 1.00 |
| Thrombocytopenia | 4 (6.8) | 5 (11.4) | 0.49 |
| Febrile neutropenia | 2 (3.4) | 3 (6.8) | 0.64 |
| Treatment delay | 27 (45.8) | 21 (47.7) | 1.00 |
| Dose reduction | 24 (40.0) | 14 (31.8) | 0.41 |
| Severe toxicity | 11 (18.6) | 14 (31.8) | 0.16 |
| Treatment mortality | 0 (0.0) | 2 (4.5) | 0.18 |
$, data on toxicity was not available for one patient submitted to treatment with standard FOLFIRINOX.