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. 2018 Aug 6;12:170. doi: 10.3389/fnbeh.2018.00170

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Copyright © 2018 Guo, Yin, Qiao, Jia, Chen, Shao, Lebaron, Gao, Shi and Jia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experiment design. Mice were injected with valproic acid (VPA) (600 mg/kg, i.p.) on pregnant day 12.5 (GD12.5) and were provided with hydrogen-rich water (HRW) during pregnant phase and after postnatal day (PND). Behavioral tests of adolescent mice offspring were conducted from PND 35 to 42. Blood samples were collected after behavioral tests for Enzyme-Linked Immune-Sorbent Assay (ELISA) assays. OFT, open field test; NSF, novelty suppressed feeding; HPT, hot plate test; SIT, social interaction test; CFC, contextual fear conditioning test.