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. 2018 Aug 6;12:170. doi: 10.3389/fnbeh.2018.00170

Figure 2.

Figure 2

HRW administration reversed the anxiety-like behaviors in maternal VPA-exposed mice offspring. Anxiety-like behaviors were assessed by the OFT and NSF test. HRW administration significantly reversed the decreased time spent in the center of both male (A) and female (E) mice offspring, while had no significant effect on the total distance (B,F) in the OFT. HRW administration significantly reversed the increased latency to feeding of both male (C) and female (G) mice offspring, while had no significant effect on the total food intake (D,H) in the NSF test. OFT, open field test; NSF, novelty suppressed feeding test. Data are expressed as the mean ± SEM. **P < 0.01, ***P < 0.005 compared with the saline-injected group (NAV); #P < 0.05, ##P < 0.01, ###P < 0.005 compared with the VPA-exposed group (VEH; n = 6–10 per group).