Fig. 5.
Vagal afferent activity is not necessary for the intravenous dihydrocapsaicin (DHC)-evoked inhibition of BAT thermogenesis. A and B: representative examples of the decreases in brown adipose tissue (BAT) sympathetic nerve activity (SNA), BAT temperature (TBAT), arterial pressure (AP), expired CO2, core body temperature (TCORE), heart rate (HR), and skin temperature (TSKIN) produced by intravenous DHC (3, 30, and 300 µg/kg, injection indicated by the vertical dashed lines) in a vagus intact rat (A) and in a rat with a bilateral cervical vagotomy (B). C: group data (means ± SE) of the BAT thermogenic and cardiovascular effects of DHC injections in vagus intact (filled circles, n = 6) and cervical vagotomized (open circles, n = 5) rats. MAP, mean arterial pressure. *P < 0.05, significant difference between the intact and vagotomized groups by t-test at the nadir of the DHC-evoked responses.