A: circulating immune cell profile after 3 wk of 4.0% high-salt challenge in Dahl salt-sensitive (SS) and SS-Rag1−/− rats fed either the normal (18%) or high (30%)-protein chow. CD45, leukocytes; CD11b/c, monocytes and macrophages; CD3, T lymphocytes; CD45R, B lymphocytes. Two-way ANOVA with Holm-Sidak post hoc test, *P < 0.01 and **P < 0.001 vs. SS. Here, 18% SS, n = 8; 30% SS, n = 7; 18% SS-Rag1−/−, n = 8; 30% SS-Rag1−/−, n = 7. B: representative flow cytometric plots demonstrating T and B lymphocyte depletion in SS-Rag1−/− rats.