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Pulmonary microvascular endothelial cells (PMVECs) are more acid resistant than are pulmonary arterial endothelial cells (PAECs) because of higher carbonic anhydrase IX (CA IX) expression and enhanced buffering capacity. PMVECs have higher CA IX expression than do PAECs; thus they more efficiently convert protons to carbon dioxide, relieving acid load. Our study suggests that CA IX is a potential mechanism of PMVEC acid resistance. Dashed lines represent low or no expression of CA IX.
